Seanol® for Weight Loss
Too much fat in the body is a major risk factor for insulin resistance and diabetes.
Proven fat loss
In two separate clinical trials, Seanol® was shown to be effective in slimming waists without any additional exercise [1,2]. Compared to the placebo, overweight adults that took Seanol® had lower body fat percentage, lower body weight, lower BMI, and better liver health indicators (ALT and AST levels) in 12 weeks without any side-effects. In another study, overweight adults with abdominal obesity had lower body fat percentage, total fat tissue area, and higher skeletal muscle index after taking Seanol® compared to placebo [9]. There were no major differences or changes in diet and exercise levels.
Stop fat production
It can be easy to gain weight again after completing a weight loss program, but Seanol® can help prevent this by suppressing body fat build-up.
Fat (triglyceride) is stored in specialized fat-storing cells called white adipocytes. Cells become adipocytes through a process called adipogenesis, which is a chain of biochemical signals. In mild obesity, adipocytes become larger in size as they store larger volumes of triglycerides. In severe obesity, a larger number of cells become adipocytes through adipogenesis. These changes increase body fat.
When Seanol® was given to mice together with a high-fat diet, they had 55% lower triglyceride levels compared to animals without Seanol®. Adipogenesis (PPARγ) was also reduced by up to 80% in the liver. In other experiments, adipocytes with Seanol® had 65% lower triglyceride levels as well as lower adipogenesis signals (PPARγ and C/EBPα by 80% and 60% respectively) [3,4,5,6].
Healthier cell metabolism
Seanol® may also help to prevent abnormal cell function with its anti-inflammatory benefits.
Obese mice on high-fat diets with Seanol® were found to have lower inflammation markers in the liver and kidneys compared to animals without Seanol®, according to two animal studies [7,8].
Summary
Seanol® can lower body fat percentage in 12 weeks without side-effects
Seanol® can prevent fat build-up and fat inflammation, which contribute to insulin resistance and diabetes complications
Sources:
https://dx.doi.org/10.1002/ptr.3559
https://dx.doi.org/10.1089/jmf.2011.1996
https://dx.doi.org/10.1002/mnfr.201500021
https://dx.doi.org/10.3390/molecules201219796
https://dx.doi.org/10.3892/ijmm.2017.2869
https://dx.doi.org/10.1016/S0092-8674(00)81359-8
https://dx.doi.org/10.1021/jf502830b
https://dx.doi.org/10.1021/acs.jafc.7b00357
https://doi.org/10.1016/j.jff.2018.04.062